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It was unclear whether testosterone administration before chemotherapy would accelerate the progression to cancer. assess this possibility, we studied a multicenter trial of 1537 men with low-grade BPH androgenetic alopecia (LHAA) treated for 3 months with finasteride 20–30 mg/day, in addition to standard treatment.
Methods
Setting and Participants
This was an observational clinical trial sponsored by the Propecia, Inc., company (San Diego, CA, United States of America) and the American Urological Association (AUA) (Fremont, CA, United States of America). The trial was approved in accordance with the Declaration of Helsinki and was conducted as an open-label, noninterventional trial, at 5 centers in the United States. All patients had received at least 1 previous dose of finasteride. Between November 2010 and March 2012, we randomly assigned 618 participants with a mean age of 49 years (range, 36 to 75 years) with male pattern hair loss to receive 20–30 mg/day, of which 20 mg/day was given before 3 wk of chemotherapy. Participants were assessed quarterly at baseline, after 3, and 6 months.
Procedures
Clinical and anthropometric evaluations were conducted with the use of a standardized protocol. Patients were excluded if they met the following exclusion criteria: (i) presence of a disease other than hypogonadism; (ii) current or recent use of systemic steroids (e.g., finasteride, dihydrotestosterone); and/or if (iii) had evidence of anemia. Patients received 2.5 mg of finasteride/kg per night intravenously in the evening before scheduled chemotherapy dose. For the second and third weeks, patients were treated with finasteride at 10 mg/day per night on evenings. days 1 and 2 of the course, patients received a single 4 mg dose of finasteride alone in the evening. These doses were followed by 4 mg doses of finasteride twice daily from the subsequent day (to achieve a total daily dose of 10 mg), for a total course of 12 weeks (total 6 mg/d). Patients were informed that because of the finasteride regimen, they would not respond to systemic oral therapy for the rest of their lifetimes.
Patients and Randomization
The trial protocol was approved by the University of California, San Francisco, Human Subjects Committee and a data safety monitoring board. All participants gave written informed consent. The trial drug was patented and trademarked product Proscar® (Elanco Products, New
Orlistat for sale in us York, NY) with active moiety 2-alpha-hydroxy-5α-pregnan-20-one (Finasteride®) for the treatment of male pattern hair loss. The study design was registered at ClinicalTrials.gov as NCT00082681. The trial enroll in-person, and randomized patients to a 4-week regimen of finasteride (n = 112), placebo 91), or a 12-week regimen of finasteride and placebo (n = 112). Patients were followed for an average of 6.4 weeks after randomization.
Appropriate Clinical Dose
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1. Finasteride Side Effects And Side-Effects Of Finasteride Hairloss
You may have a wide variety of side effects with finasteride, including:
headache (6% of users)
dizziness (2% of users), headaches (6% users)
nausea (3% of users),
redness (2% of users), skin changes dryness (2% of users)
hair loss (8% of users),
increased menstrual flow during the first few months (6% of users),
increased hair growth (8% of users),
loss of hair (8% users),
possible depression and anxiety (8% of users),
dizziness (8% of users),
decreased sexual drive (5% of users), decreased sperm count (4 to 6% of users)
fatigue (8% of users),
increased susceptibility to infection (4% of users),
increased appetite to fat loss (4% of users),
problems falling and sitting (7% of users), problems sleeping (5% users)
loss of body hair (5% users), skin irritation (3.5% of
red blood cell (10% of users), increased risk cancer (3% of users)
2. What Does Finasteride Do? How Long It Last?
Finasteride is a synthetic steroid medication, which works by decreasing levels of type II androgen. Androgen hormones make up the majority of hair in your body. These hormones are responsible for building the hair that you get. When a person who has had too much of this type steroid becomes balding because of prostate cancer, testosterone is the culprit. Androgens are important in keeping hair from growing on androgens are essential to hair growth. When you take finasteride, are temporarily shutting down these hormones or taking away the body's ability to absorb them from your blood. This causes the body to become deficient in the amount of androgens that it needs. This in turn causes the hormones to not be converted the hormones they are designed to convert into. Without the body's ability to naturally convert the sex hormones, hair finasteride 2.5 mg hair loss growth ceases and loss occurs.
Since it is also a type-II adrenal steroid, which is responsible for converting to diuretics and also helps produce catecholamines (stress hormones), finasteride has the ability to cause a myriad of unwanted symptoms, 5mg finasteride hair loss such as:
fatigue,
increased frequency of urination (5% users),
constipation,
inhalation of urine (2% users),
heart disease
and heart failure.
However, since there is very little known about the long-term effects of finasteride use, in many cases patients with these side effects do feel normal and not notice their symptoms.
3. Finasteride & Pregnancy
Many drugs that inhibit the production of diuretics that are in use as "water pills" can also result in excessive blood pressure rise and lead to premature birth or possible miscarriage in your pregnancy. This is because the diuretics decrease amount of urine a pregnant woman produces and also reduce the amount of blood in baby's lungs and placenta, because of the low level sodium in blood. This, turn, is why this drug can be dangerous for a pregnant woman. Some women may suffer from excessive swelling, weight gain, depression, and low thyroid function. Also, some pregnant women will actually experience high blood pressure, urine output, and even abnormal heart.
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